Hydroxyapatite (nano) in EU cosmetics: Annex III, entry 372
Hydroxyapatite (nano): maximum concentration in ready for use preparation by product type: (a) Toothpaste (b) Mouthwash: (a) 10 % (b) 0,465 %. Annex III, entry 372, Regulation (EC) No 1223/2009, consolidated 18 May 2026.
- Annex
- III: List of substances which cosmetic products must not contain except subject to the restrictions laid down
- Reference number
- 372
- Chemical name/INN
- Hydroxyapatite (43)
- Name of Common Ingredients Glossary
- Hydroxyapatite (nano)
- CAS number
- 1306-06-5
- EC number
- 215-145-7
- Version
- Consolidated version of 18 May 2026
- Official source
- Regulation (EC) No 1223/2009, consolidated text
Official wording: restrictions
- Product type, body parts: (a) Toothpaste (b) Mouthwash | Maximum concentration in ready for use preparation: (a) 10 % (b) 0,465 % | Other: For (a) and (b): Not to be used in applications that may lead to exposure of the end-user’s lungs by inhalation. Only nanomaterials having the following characteristics are allowed: - [composed of] rod-shaped particles of which at least 95,8 % (in particle number) have an aspect ratio less than 3, and the remaining 4,2 % have an aspect ratio not exceeding 4,9; - the particles are not coated or surface modified
Notes referred to in this entry
- (43) From 1 February 2025 cosmetic products containing that substance and not complying with the restrictions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not complying with the restrictions shall not be made available on the Union market.
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