4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt in EU cosmetics: Annex III, entry 226
4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt: the entry states a maximum concentration of (b) 1,2 % as free base (1,8 % as tetrahydrochloride salt); its other lines add conditions, see below. Annex III, entry 226, consolidated 18 May 2026.
- Annex
- III: List of substances which cosmetic products must not contain except subject to the restrictions laid down
- Reference number
- 226
- Chemical name/INN
- 4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (17)
- Name of Common Ingredients Glossary
- 1,3-bis-(2,4-Diaminophenoxy)propane, 1,3-bis-(2,4-Diaminophenoxy)propane HCl
- CAS number
- 81892-72-0 / 74918-21-1
- EC number
- 279-845-4 / 278-022-7
- Version
- Consolidated version of 18 May 2026
- Official source
- Regulation (EC) No 1223/2009, consolidated text
Official wording: restrictions
- Product type, body parts: (a) Hair dye substance in oxidative hair dye products | Other: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,2 % calculated as free base (1,8 % as tetrahydrochloride salt).
- Product type, body parts: (b) Hair dye substance in non-oxidative hair dye products | Maximum concentration in ready for use preparation: (b) 1,2 % as free base (1,8 % as tetrahydrochloride salt)
Official wording: conditions of use and warnings
(a) To be printed on the label:
The mixing ratio.
‘ [pictogram in the official text] Hair colourants can cause severe allergic reactions.
Read and follow instructions.
This product is not intended for use on persons under the age of 16.
Temporary “black henna” tattoos may increase your risk of allergy.
Do not colour your hair if:
- you have a rash on your face or sensitive, irritated and damaged scalp,
- you have ever experienced any reaction after colouring your hair,
- you have experienced a reaction to a temporary “black henna” tattoo in the past.’
(b) Can cause allergic reaction
Notes referred to in this entry
- (17) The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use.
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